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Risk of antidepressant‐associated mortality
Author(s) -
Lam Y. W. Francis
Publication year - 2016
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30145
Subject(s) - antidepressant , medicine , tricyclic antidepressant , depression (economics) , tricyclic , stroke (engine) , adverse effect , sudden cardiac death , drug , psychiatry , intensive care medicine , cardiology , pharmacology , hippocampus , mechanical engineering , engineering , economics , macroeconomics
It is not unusual for patients to exhibit depressive symptoms after suffering a stroke. Although effective in managing depression, some antidepressants are believed to carry a risk of additional adverse cardiovascular and cerebrovascular effects, as well as the potential for drug‐drug interaction. Such adverse effects include conduction abnormalities and sudden death from the use of tricyclic antidepressant (TCA) drugs, and the possibility of sudden cardiac death associated with selective serotonin reuptake inhibitors (SSRIs). 1 , 2 In addition, there are conflicting data in the literature regarding the association between antidepressant use and stroke. Although the exact mechanism is unknown, thicker arteries related to antidepressant use have been suggested as a plausible explanation. 3