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Immunoglobulin M deficiency in clozapine‐treated patients
Author(s) -
Lam Y. W. Francis
Publication year - 2016
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30116
Subject(s) - clozapine , medicine , schizophrenia (object oriented programming) , antibody , antipsychotic drug , immunology , antipsychotic , drug , atypical antipsychotic , pharmacology , psychiatry
The atypical antipsychotic clozapine has demonstrated effectiveness in managing patients with treatment‐resistant schizophrenia. However, the drug also affects levels of antibody‐producing cytokines and possesses immunosuppressive activity, and therefore could affect humoral immunity. 1 A recent report investigated the relationship between long‐term clozapine treatment and the occurrence of selective immunoglobulin M deficiency, a rare dysgammaglobulinemia that occurs in the setting of normal T‐cell number. 2