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Antidepressants block effect of D‐cycloserine in OCD treatment
Publication year - 2015
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30101
Subject(s) - cycloserine , placebo , psychopharmacology , partial agonist , antidepressant , psychology , concomitant , medicine , psychiatry , pharmacology , psychotherapist , clinical psychology , anxiety , agonist , alternative medicine , tuberculosis , receptor , pathology
The effects of the partial N‐methyl‐D‐aspartate (NMDA) agonist D‐cycloserine in augmenting cognitive behavioral therapy (CBT) in patients with obsessive‐compulsive disorder (OCD) were blocked in individuals taking an antidepressant concurrently, a new study has found. Concomitant antidepressant use did not have any effect in a group of patients receiving placebo in the study.