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Hormone withdrawal engenders depressive symptoms in women with PMD
Publication year - 2015
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30074
Subject(s) - psychopharmacology , depression (economics) , depressive symptoms , hormone , medicine , psychiatry , psychology , clinical psychology , anxiety , economics , macroeconomics
Women with a history of perimenopausal depression (PMD) who were withdrawn from hormonal therapy with estradiol experienced a significant increase in depressive symptom severity compared with women with past PMD who remained on estradiol and women with no PMD history, a new study has found. The findings suggest that normal changes in estradiol secretion can generate an abnormal behavioral state in women susceptible to depression. Study results were published online May 27, 2015, in JAMA Psychiatry .