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Tramadol‐induced mania in a patient with depression
Author(s) -
Lam Y. W. Francis
Publication year - 2015
Publication title -
the brown university psychopharmacology update
Language(s) - English
Resource type - Journals
eISSN - 1556-7532
pISSN - 1068-5308
DOI - 10.1002/pu.30035
Subject(s) - tramadol , antidepressant , reuptake inhibitor , serotonin reuptake inhibitor , serotonin , tricyclic , norepinephrine , tricyclic antidepressant , medicine , pharmacology , mania , serotonin uptake inhibitors , reuptake , anesthesia , norepinephrine transporter , fluoxetine , analgesic , bipolar disorder , dopamine , receptor , hippocampus , lithium (medication)
It is not unusual for patients with co‐occurring chronic pain and depression to receive concurrent administration of an antidepressant (e.g., a tricyclic antidepressant [TCA], selective serotonin reuptake inhibitor [SSRI], or serotonin‐norepinephrine reuptake inhibitor [SNRI]) and tramadol, which is sometimes preferred in place of more potent analgesics. However, tramadol also can have an inhibitory effect on serotonin and norepinephrine uptake, and concurrent administration of an antidepressant and tramadol could result in undesirable side effects associated with increased serotonin and norepinephrine neurotransmission.