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Screening of selected plant extracts for in vitro inhibitory activity on Human Immunodeficiency Virus
Author(s) -
Bedoya L. M.,
Palomino S. Sanchez,
Abad M. J.,
Bermejo P.,
Alcami J.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.992
Subject(s) - traditional medicine , in vitro , officinalis , pharmacognosy , medicinal plants , cytotoxicity , mtt assay , aqueous extract , minimum inhibitory concentration , medicine , pharmacology , biology , biological activity , biochemistry
As part of our screening of anti‐AIDS agents from natural sources, extracts of 15 medicinal plants widely used in the folk medicines of North America and Europe were evaluated in vitro . Most of the extracts tested were relatively nontoxic to human lymphocytic MT‐2 cells, but only the extracts of Hysopp officinalis and Dittrichia viscosa exhibited anti‐HIV activity in an in vitro MTT assay. The 50% hydroalcohol extract of Hysopp officinalis and the aqueous extract of Dittrichia viscosa showed inhibitory effects against HIV‐1 induced infections in MT‐2 cells at concentrations ranging from 50 to 100 μg/mL and 25 to 400 μg/mL, respectively. Both extracts showed no appreciable cytotoxicity at these concentrations. Copyright © 2002 John Wiley & Sons, Ltd.