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In vitro Immunomodulatory activity of verbascoside from Nepeta ucrainica L.
Author(s) -
Akbay Pinar,
Calis Ihsan,
Ündeger Ülkü,
Basaran Nursen,
Basaran A. Ahmet
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.990
Subject(s) - verbascoside , phytochemical , in vitro , traditional medicine , iridoid , chemistry , nepeta , chemotaxis , biology , biochemistry , pharmacology , stereochemistry , medicine , lamiaceae , glycoside , receptor
Nepeta ucrainica L. is used as a herbal tea in Kazakhistan. Phytochemical investigations of the aerial parts of the plant resulted in the isolation of verbascoside (1) and 1,5,9‐ epi ‐deoxyloganic acid (2). The structures of the compounds were elucidated by spectral (UV, IR, 1 H‐NMR and 13 C‐NMR) methods and HPLC analysis. The in vitro immunomodulatory activity of verbascoside was investigated by assessing neutrophil function; chemotaxis and intracellular killing activity. Verbascoside showed an increased chemotactic activity in all doses applied compared with the medium used as a negative control and had a positive effect on respiratory burst of neutrophils, but there was an opposite effect with increasing doses, pointing to a possible suppression of neutrophil intracellular killing activity. Copyright © 2002 John Wiley & Sons, Ltd.