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Glucose lowering efficacy of Ficus racemosa bark extract in normal and alloxan diabetic rats
Author(s) -
Bhaskara Rao R.,
Murugesan T.,
Sinha Sanghamitra,
Saha B. P.,
Pal M.,
Mandal Subhash C.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.988
Subject(s) - glibenclamide , alloxan , ficus , moraceae , traditional medicine , bark (sound) , pharmacognosy , medicine , diabetes mellitus , pharmacology , biological activity , chemistry , biology , botany , endocrinology , biochemistry , ecology , in vitro
Abstract The glucose‐lowering efficacy of a methanol extract of the stem bark of Ficus racemosa Linn. (MEBFR) (Family Moraceae) was evaluated both in normal and alloxan‐induced diabetic rats. The MEBFR at the doses examined (200 and 400 mg/kg p.o.) exhibited significant hypoglycaemic activity in both experimental animal models when compared with the control group. The activity was also comparable to that of the effect produced by a standard antidiabetic agent, glibenclamide 10 mg/kg. The present investigation established pharmacological evidence to support the folklore claim that it is an antidiabetic agent. Copyright © 2002 John Wiley & Sons, Ltd.