Premium
Abietic acid inhibits lipoxygenase activity
Author(s) -
Ulusu N. Nuray,
Ercil Dilek,
Sakar M. Koray,
Tezcan E. Ferhan
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.983
Subject(s) - abietic acid , abietane , lipoxygenase , chemistry , terpenoid , arachidonate 5 lipoxygenase , biosynthesis , diterpene , biochemistry , stereochemistry , enzyme , organic chemistry , resin acid , arachidonic acid , rosin
Abstract In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5‐lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC 50 of 29.5 ± 1.29 µ M was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions. Copyright © 2002 John Wiley & Sons, Ltd.