Abietic acid inhibits lipoxygenase activity | Zendy

Ulusu N. Nuray | Zendy; Ercil Dilek | Zendy; Sakar M. Koray | Zendy; Tezcan E. Ferhan | Zendy

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Abietic acid inhibits lipoxygenase activity

Author(s) -

Ulusu N. Nuray,

Ercil Dilek,

Sakar M. Koray,

Tezcan E. Ferhan

Publication year - 2002

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.983

Subject(s) - abietic acid , abietane , lipoxygenase , chemistry , terpenoid , arachidonate 5 lipoxygenase , biosynthesis , diterpene , biochemistry , stereochemistry , enzyme , organic chemistry , resin acid , arachidonic acid , rosin

In this study, it was shown that abietic acid, an abietane diterpenoid, inhibited soybean 5‐lipoxygenase (linoleate: oxygen oxidoreductase, EC 1.13.11.12) and an IC 50 of 29.5 ± 1.29 µ M was determined. Since the lipoxygenase pathway leads to the biosynthesis of leukotrienes this result supports the view that abietic acid may be used in the treatment of allergic reactions. Copyright © 2002 John Wiley & Sons, Ltd.

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