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Human platelet aggregation inhibitors from thyme ( Thymus vulgaris L.)
Author(s) -
Okazaki Kenji,
Kawazoe Kazuyoshi,
Takaishi Yoshihisa
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.979
Subject(s) - thymus vulgaris , arachidonic acid , thymol , thrombin , chemistry , platelet aggregation , platelet , pharmacognosy , stereochemistry , biochemistry , biological activity , in vitro , enzyme , biology , chromatography , immunology , essential oil
Two antiaggregant compounds, thymol (compound 1) and 3,4,3′,4′‐tetrahydroxy‐5,5′‐diisopropyl‐2,2′‐dimethylbiphenyl (compound 2) were isolated from the leaves of thyme ( Thymus vulgaris L.). The structures were determined by 1 H‐, 13 C‐NMR and mass spectra (MS) studies. These compounds inhibited platelet aggregation induced by collagen, ADP, arachidonic acid (AA) and thrombin except that compound 2 did not inhibit platelet aggregation induced by thrombin. Copyright © 2002 John Wiley & Sons, Ltd.