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Antipruritic and antidermatitic effect of extract and compounds of Impatiens balsamina L. in atopic dermatitis model NC mice
Author(s) -
Oku Hisae,
Ishiguro Kyoko
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.964
Subject(s) - atopic dermatitis , scratching , antipruritic , medicine , pharmacognosy , traditional medicine , dermatology , pharmacology , chemistry , biological activity , biochemistry , physics , acoustics , in vitro
Abstract We examined the effects of a 35% ethanol extract (IB) from the petals of Impatiens balsamina L. and the principal active compounds from IB on chronic and serious pruritus and the development of dermatitis using NC mice, a model of atopic dermatitis. IB at 100 mg/kg significantly inhibited serious scratching behaviour in the NC mouse with established dermatitis when administered i.v. 1 h before, or p.o. 24 h before the measurement. A 10 μg/kg dose of kaempferol 3‐rutinoside and 2‐hydroxy‐1, 4‐naphthoquinone (lawsone) isolated from IB also inhibited scratching behaviour in the NC mouse with established dermatitis. When 4‐week‐old NC mice with no symptoms were administered orally 100 mg/kg/day of IB until 13 weeks of age, protection was also noted against scratching behaviour during the development of dermatitis. IB was effective for the prevention and treatment of atopic dermatitis. Copyright © 2001 John Wiley & Sons, Ltd.