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Antidiarrhoeal activity of seed extract of Albizzia lebbeck Benth.
Author(s) -
Besra S. E.,
Gomes A.,
Chaudhury L.,
Vedasiromoni J. R.,
Ganguly D. K.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.961
Subject(s) - antidiarrhoeal , loperamide , traditional medicine , castor oil , medicine , dysentery , pharmacology , chemistry , diarrhea , biochemistry , pathology
Abstract The antidiarrhoeal activity of the seed extract of Albizzia lebbeck (Benth.) was investigated employing conventional rodent models of diarrhoea, i.e. castor oil‐induced diarrhoea, upper gastrointestinal transit (u.g.t.) and fluid secretion. It was found that the aqueous methanol extract of Albizzia lebbeck seeds (2.5–5 mg/kg i.p.) possessed antidiarrhoeal activity which strengthens the earlier use of the seeds in the treatment of diarrhoea and dysentery. The antidiarrhoeal dose of the extract was at least 10–30 times less than the LD 50 dose. The extract (2.5–5 mg/kg i.p.) potentiated the antidiarrhoeal activity of loperamide (1 mg/kg i.p.). Nalaxone (0.5 mg/kg i.p.) significantly inhibited the antidiarrhoeal activity of the extract as well as loperamide, thus indicating a role of the opioid system in the antidiarrhoeal activity of the extract. Copyright © 2002 John Wiley & Sons, Ltd.