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ent ‐Kaur‐16‐en‐19‐oic acid, a KB cells cytotoxic diterpenoid from Elaeoselinum foetidum
Author(s) -
Mongelli E.,
Pomilio A. B.,
Sánchez J. Bustamante,
Guerra F. M.,
Massanet G. Martínez
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.955
Subject(s) - terpenoid , diterpene , cytotoxic t cell , traditional medicine , pharmacognosy , stereochemistry , biology , chemistry , medicine , in vitro , biological activity , biochemistry
Toxic and cytotoxic activities of the toxic plant Elaeoselinum foetidum (Apiaceae) were evaluated using the brine shrimp toxicity (BST) and KB cell cytotoxicity assays. The active chloroform extract was subjected to a bioactivity‐directed fractionation, monitored by the BST assay, that led to the isolation of the diterpenoid ent ‐kaur‐16‐en‐19‐oic acid. This compound was potent against the brine shrimp (LC 50 = 4.8 μg/mL) and KB cells (IC 50 = 1.6 μg/mL). Copyright © 2002 John Wiley & Sons, Ltd.