In vitro  Inhibition of HHV‐6 replication by sophocarpines | Zendy

Qavi Hamida B. | Zendy; Wyde Philip R. | Zendy; Khan Mushtaq A. | Zendy

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In vitro Inhibition of HHV‐6 replication by sophocarpines

Author(s) -

Qavi Hamida B.,

Wyde Philip R.,

Khan Mushtaq A.

Publication year - 2002

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.949

Subject(s) - replication (statistics) , in vitro , strain (injury) , cytotoxic t cell , biology , virology , viral replication , chemistry , microbiology and biotechnology , stereochemistry , genetics , virus , anatomy

The virostatic activity of sophocarpines and gancyclovir (GCV) was tested using HHV‐6 Z29 strain and Molt‐3 cells. The cytotoxic (IC 50 ) and the antiviral (ED 50 ) values were first experimentally determined and selective indices (SI) were then calculated. The SI values for sophocarpines 1 and 2 and GCV were in the order 184, 183, and 23, respectively. Though preliminary, these findings indicate that sophocarpines have the potential to inhibit HHV‐6 replication. Copyright © 2002 John Wiley & Sons, Ltd.

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