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In vitro Inhibition of HHV‐6 replication by sophocarpines
Author(s) -
Qavi Hamida B.,
Wyde Philip R.,
Khan Mushtaq A.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.949
Subject(s) - replication (statistics) , in vitro , strain (injury) , cytotoxic t cell , biology , virology , viral replication , chemistry , microbiology and biotechnology , stereochemistry , genetics , virus , anatomy
The virostatic activity of sophocarpines and gancyclovir (GCV) was tested using HHV‐6 Z29 strain and Molt‐3 cells. The cytotoxic (IC 50 ) and the antiviral (ED 50 ) values were first experimentally determined and selective indices (SI) were then calculated. The SI values for sophocarpines 1 and 2 and GCV were in the order 184, 183, and 23, respectively. Though preliminary, these findings indicate that sophocarpines have the potential to inhibit HHV‐6 replication. Copyright © 2002 John Wiley & Sons, Ltd.