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Anxiolytic and antiemetic activity of Zingiber officinale
Author(s) -
Vishwakarma S. L.,
Pal S. C.,
Kasture Veena S.,
Kasture S. B.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.948
Subject(s) - anxiolytic , antiemetic , anticonvulsant , rhizome , pharmacology , diazepam , zingiber officinale , chemistry , motor activity , petroleum ether , medicine , anesthesia , traditional medicine , biochemistry , chromatography , epilepsy , receptor , psychiatry , extraction (chemistry) , vomiting
The benzene fraction (BF) of a petroleum ether extract of dried rhizomes of ginger, which contained anticonvulsant principle(s), was screened for anxiolytic and antiemetic activity. Motor coordination was not affected by BF per se , but diazepam‐induced motor incoordination was potentiated. Animals treated with BF showed decreased occupancy in the closed arm of the elevated plus maze suggesting the presence of anxiolytic principles in the BF. BF also blocked lithium sulphate‐induced conditioned place aversion indicating antiemetic activity. These findings suggest that the fraction (BF) possesses anticonvulsant, anxiolytic and antiemetic activity. Copyright © 2002 John Wiley & Sons, Ltd.