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The antiulcer activity of Garcinia cambogia extract against indomethacin‐induced gastric ulcer in rats
Author(s) -
Mahendran P.,
Vanisree A. J.,
Shyamala Devi C. S.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.946
Subject(s) - garcinia , pharmacognosy , traditional medicine , phytotherapy , gastric mucosa , oral administration , pharmacology , chemistry , medicine , stomach , biological activity , biochemistry , pathology , in vitro , alternative medicine
Garcinia cambogia extract is a herbal preparation that has been suggested as useful in the treatment of gastrointestinal disorders. In the present study this drug was tested for its antiulcerogenic effect. Oral pretreatment with Garcinia cambogia fruit extract (1 g/kg body wt/day) for 5, 10 or 15 days protected the gastric mucosa against the damage induced by indomethacin (20 mg/kg body wt). The volume and acidity of the gastric juice decreased in the pretreated rats. The glycoprotein levels of the gastric contents which were decreased in the untreated rats, maintained near normal levels in the pretreated rats. Protein which was elevated in the gastric juice of untreated rats, showed near normal levels in the pretreated rats. Garcinia cambogia was able to decrease the acidity and to increase the mucosal defence in the gastric areas, thereby justifying its use as an antiulcerogenic agent. Copyright © 2002 John Wiley & Sons, Ltd.