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Aloe arborescens extract inhibits TPA‐induced ear oedema, putrescine increase and tumour promotion in mouse skin
Author(s) -
Shimpo Kan,
Ida Chikako,
Chihara Takeshi,
Beppu Hidehiko,
Kaneko Takaaki,
Kuzuya Hiroshi
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.938
Subject(s) - putrescine , tumor promotion , acetone , ethyl acetate , traditional medicine , tetradecanoylphorbol acetate , chemistry , pharmacology , pharmacognosy , medicine , biochemistry , biological activity , in vitro , enzyme , carcinogenesis , protein kinase c , gene
The ethyl acetate extract of the acetone‐soluble Aloe arborescens fraction was found to inhibit 12‐ O ‐tetradecanoylphorbol‐13‐acetate (TPA)‐induced ear oedema, putrescine increase and tumour promotion in mouse skin. Chromatographic analyses of this extract revealed that phenolic compounds such as aloenin, barbaloin and isobarbaloin could be useful as cancer chemopreventive agents against tumour promotion. Copyright © 2002 John Wiley & Sons, Ltd.