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Jasmine absolute ( Jasminum grandiflora L.) and its mode of action on guinea‐pig ileum in vitro
Author(s) -
LisBalchin M.,
Hart S.,
Wan Hang Lo B.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.935
Subject(s) - guinea pig , in vitro , traditional medicine , ileum , mode of action , biology , chemistry , botany , medicine , toxicology , biochemistry , endocrinology
Jasmine ( Jasminum grandiflorum L.) is used in aromatherapy as a holistic treatment for apathy, hysteria, uterine disorders and childbirth, muscle relaxation and coughs. Its stimulant nature, on inhalation, has been shown both in animals and man. Jasmine has a spasmolytic activity on guinea‐pig ileum and rat uterus in vitro . The mechanism of action of the spasmolytic activity, studied in vitro using a guinea‐pig ileum smooth muscle preparation, was postsynaptic and not atropine‐like. The spasmolytic effect of jasmine absolute was most likely to be mediated through cAMP, and not through cGMP. The mode of action in vitro resembled that of geranium, lavender and peppermint oils. The contradictory effect in vitro and in vivo is probably due to the solely physiological effects of jasmine absolute in vitro (producing a relaxation) compared with that in vivo , where it has a strong psychological input, producing a stimulant effect in man and enhanced movement in animals. Copyright © 2002 John Wiley & Sons, Ltd.