Premium
Antiulcerogenic and analgesic effects of the Austroplenckia populnea extracts in mice
Author(s) -
Seito L. N.,
Mazaro R.,
Di Stasi L. C.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.932
Subject(s) - celastraceae , analgesic , traditional medicine , ethanol , pharmacognosy , pharmacology , phytotherapy , terpene , chemistry , tail flick test , lesion , oral administration , acute toxicity , toxicity , medicine , biological activity , in vitro , nociception , biochemistry , stereochemistry , surgery , pathology , alternative medicine , receptor , organic chemistry
Austroplenckia populnea (Reiss.) Lund. is a Brazilian Cerrado plant belonging to the Celastraceae family. Hexane and methanol extracts of leaves were investigated for their antiulcerogenic (ethanol and indomethacin/bethanecol induced gastric damage) and analgesic (writhing and tail‐flick tests) activities in mice. Acute toxic effects also were evaluated. Oral administration of both extracts at a dose of 1000 mg/kg significantly reduced the total area of the lesion, the relative area of lesion and the ulcerative index in ethanol‐induced gastric damage, but both extracts were inactive in the indomethacin/bethanecol‐induced gastric damage test. A dose dependent effect was determined with the hexane extract in the ethanol‐induced lesions test. The hexane and methanol extracts reduced the number of contortions in the writhing test, but both extracts were inactive in the tail‐flick immersion test. Copyright © 2002 John Wiley & Sons, Ltd.