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Action of Rubus coreanus extract on systemic and local anaphylaxis
Author(s) -
Shin TaeYong,
Kim SangHyun,
Lee EunSoon,
Eom DongOk,
Kim HyungMin
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.925
Subject(s) - anaphylaxis , histamine , pharmacology , immunoglobulin e , medicine , compound 48/80 , mast cell , allergy , chemistry , traditional medicine , immunology , antibody , receptor , degranulation
The effect was investigated of the aqueous extract of Rubus coreanus Miq. (Rosaceae) fruits (RCAE) on systemic and local anaphylaxis. RCAE (0.01–1 g/kg) dose‐dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. RCAE (1 g/kg) also significantly inhibited local anaphylaxis activated by anti‐DNP IgE. Pretreatment with RCAE at the same concentration before systemic anaphylaxis reduced the plasma histamine levels in a dose‐dependent manner. RCAE (0.001–1 mg/mL) dose‐dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti‐DNP IgE. The level of cAMP in RPMC, when RCAE was added, significantly increased, compared with that of the normal control. Moreover, RCAE (0.01–1 mg/mL) had a significant inhibitory effect on anti‐DNP IgE‐induced tumour necrosis factor‐α production from RPMC. These results indicate that RCAE may possess antianaphylactic action. Copyright © 2002 John Wiley & Sons, Ltd.