Action of   Rubus coreanus  extract on systemic and local anaphylaxis | Zendy

Shin TaeYong | Zendy; Kim SangHyun | Zendy; Lee EunSoon | Zendy; Eom DongOk | Zendy; Kim HyungMin | Zendy

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Action of Rubus coreanus extract on systemic and local anaphylaxis

Author(s) -

Shin TaeYong,

Kim SangHyun,

Lee EunSoon,

Eom DongOk,

Kim HyungMin

Publication year - 2002

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.925

Subject(s) - anaphylaxis , histamine , pharmacology , immunoglobulin e , medicine , compound 48/80 , mast cell , allergy , chemistry , traditional medicine , immunology , antibody , receptor , degranulation

The effect was investigated of the aqueous extract of Rubus coreanus Miq. (Rosaceae) fruits (RCAE) on systemic and local anaphylaxis. RCAE (0.01–1 g/kg) dose‐dependently inhibited systemic anaphylaxis induced by compound 48/80 in mice. RCAE (1 g/kg) also significantly inhibited local anaphylaxis activated by anti‐DNP IgE. Pretreatment with RCAE at the same concentration before systemic anaphylaxis reduced the plasma histamine levels in a dose‐dependent manner. RCAE (0.001–1 mg/mL) dose‐dependently inhibited the histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti‐DNP IgE. The level of cAMP in RPMC, when RCAE was added, significantly increased, compared with that of the normal control. Moreover, RCAE (0.01–1 mg/mL) had a significant inhibitory effect on anti‐DNP IgE‐induced tumour necrosis factor‐α production from RPMC. These results indicate that RCAE may possess antianaphylactic action. Copyright © 2002 John Wiley & Sons, Ltd.

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