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Screening of Chinese and Mongolian herbal drugs for anti‐human immunodeficiency virus type 1 (HIV‐1) activity
Author(s) -
Ma Chaomei,
Nakamura Norio,
Miyashiro Hirotsugu,
Hattori Masao,
Komatsu Katsuko,
Kawahata Takuya,
Otake Toru
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.922
Subject(s) - traditional medicine , pharmacognosy , medicinal plants , cytopathic effect , virus , human immunodeficiency virus (hiv) , phytotherapy , bioassay , fractionation , biology , biological activity , virology , medicine , pharmacology , in vitro , chemistry , biochemistry , chromatography , alternative medicine , pathology , genetics
Water and methanol extracts of 30 Chinese and Mongolian medicinal plants were tested for their human immunodeficiency virus type‐1 (HIV‐1) inhibitory activity. Of the 60 extracts, 23 showed anti‐HIV ac‐tivity. Bioassay‐guided fractionation of one of the most active extracts, the methanol extract of the root tuber of Stephania cepharantha , led to the isolation of two alkaloids, aromoline and FK‐3000 as potent inhibitory substances. They completely inhibited the cytopathic effects of HIV‐1 on MT‐4 cells at 31.3 and 7.8 μg/mL, respectively. Copyright © 2002 John Wiley & Sons, Ltd.