Inhibitory effects of Korean medicinal plants and camelliatannin H from  Camellia japonica  on human immunodeficiency virus type 1 protease | Zendy

Park Jong Cheol | Zendy; Hur Jong Moon | Zendy; Park Ju Gwon | Zendy; Hatano Tsutomu | Zendy; Yoshida Takashi | Zendy; Miyashiro Hirotsugu | Zendy; Min Byung Sun | Zendy; Hattori Masao | Zendy

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Inhibitory effects of Korean medicinal plants and camelliatannin H from Camellia japonica on human immunodeficiency virus type 1 protease

Author(s) -

Park Jong Cheol,

Hur Jong Moon,

Park Ju Gwon,

Hatano Tsutomu,

Yoshida Takashi,

Miyashiro Hirotsugu,

Min Byung Sun,

Hattori Masao

Publication year - 2002

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.919

Subject(s) - traditional medicine , protease , biology , japonica , hiv 1 protease , pharmacognosy , medicinal plants , virus , enzyme , botany , biological activity , virology , biochemistry , in vitro , medicine

To identify substances with anti‐human immunodeficiency virus (HIV) activity in traditional medicines, 101 extracts of Korean medicinal plants were screened for their inhibitory effects on HIV type 1 protease (PR). The enzyme activity was determined by HPLC. Of the extracts tested, strong inhibitory effects were observed in the acetone extracts of the pericarp and leaves of Camellia japonica , the water extract of the leaves of Sageretia theezans and the methanol extract of the aerial part of Sophora flavescens . Camelliatannin H from the pericarp of C. japonica , showed a potent inhibitory activity on HIV‐1 PR with IC 50 of 0.9 μ M . Copyright © 2002 John Wiley & Sons, Ltd.

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