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Inhibitory effects of Korean medicinal plants and camelliatannin H from Camellia japonica on human immunodeficiency virus type 1 protease
Author(s) -
Park Jong Cheol,
Hur Jong Moon,
Park Ju Gwon,
Hatano Tsutomu,
Yoshida Takashi,
Miyashiro Hirotsugu,
Min Byung Sun,
Hattori Masao
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.919
Subject(s) - traditional medicine , protease , biology , japonica , hiv 1 protease , pharmacognosy , medicinal plants , virus , enzyme , botany , biological activity , virology , biochemistry , in vitro , medicine
To identify substances with anti‐human immunodeficiency virus (HIV) activity in traditional medicines, 101 extracts of Korean medicinal plants were screened for their inhibitory effects on HIV type 1 protease (PR). The enzyme activity was determined by HPLC. Of the extracts tested, strong inhibitory effects were observed in the acetone extracts of the pericarp and leaves of Camellia japonica , the water extract of the leaves of Sageretia theezans and the methanol extract of the aerial part of Sophora flavescens . Camelliatannin H from the pericarp of C. japonica , showed a potent inhibitory activity on HIV‐1 PR with IC 50 of 0.9 μ M . Copyright © 2002 John Wiley & Sons, Ltd.