Premium
Antiinflammatory activity from aerial parts of Baccharis Medullosa, Baccharis rufescens and Laennecia sophiifolia in mice
Author(s) -
Cifuente Diego A.,
Simirgiotis Mario J.,
Favier L. Silvina,
Rotelli Alejandra E.,
Pelzer Lilian E.
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.911
Subject(s) - baccharis , acetone , chloroform , chemistry , traditional medicine , pharmacognosy , hexane , pharmacology , stereochemistry , chromatography , biological activity , medicine , botany , biology , organic chemistry , biochemistry , asteraceae , in vitro
The antiinflammatory activities of ten organic extracts from the aerial parts of Baccharis medullosa DC., Baccharis rufescens S. and Laennecia sophiifolia (Kunth) G. L. Nesom were investigated in mice subjected to carrageenan induced paw oedema. Intraperitoneally administered organic extracts given at doses equivalent to 80 mg/kg of material inhibited the acute phases of inflammation in this model. Our results indicate that the most effective extracts were: n ‐hexane ( I ) from B. medullosa , acetone ( V ) and chloroform ( VII ) from L. sophiifolia , and acetone ( VIII ) and chloroform ( X ) from B. rufescens . All exerted the strongest effect at 5 h after injection of the phlogistic agent. Copyright © 2001 John Wiley & Sons, Ltd.