Premium
Cytotoxic flavonoids from the stem bark of Lonchocarpus aff. fluvialis
Author(s) -
Blatt Cecília T. T.,
Chávez Daniel,
Chai Heebyung,
Graham James G.,
Cabieses Fernando,
Farnsworth Norman R.,
Cordell Geoffrey A.,
Pezzuto John M.,
Kinghorn A. Douglas
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.889
Subject(s) - dibenzoylmethane , chalcone , chemistry , bark (sound) , traditional medicine , cancer cell lines , stereochemistry , flavonoid , pharmacognosy , epidermoid carcinoma , botany , biology , biological activity , biochemistry , cancer cell , cancer , organic chemistry , medicine , in vitro , antioxidant , ecology , genetics
Activity‐guided fractionation of a chloroform‐soluble extract of Lonchocarpus aff. fluvialis stem bark using a human epidermoid (KB) tumour cell line as a monitor afforded five rotenoids, one pterocarpan, one chalcone, three flavanones, one flavone and one triterpenoid. All of the compounds isolated proved to be of previously known structure. Among them, the rotenoids (−)‐sumatrol and (±)‐villosinol, the dibenzoylmethane derivative (+)‐3,4‐methylenedioxy‐2′‐methoxy‐[2″,3″:4′,3′]‐furanodibenzoylmethane, and the flavanones (−)‐isoglabrachromene and (−)‐candidone have been shown to exhibit significant cytotoxic activity against human cancer cells for the first time. This is the first report of the chemical constituents of this species, and the profile of compounds obtained was in accordance with the established chemosystematic patterns of species in the tribe Tephrosieae (Leguminosae, Papilionoideae). Copyright © 2002 John Wiley & Sons, Ltd.