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Neurophysiological Effects of an Extract of Eschscholzia californica Cham. ( Papaveraceae )
Author(s) -
Rolland A.,
Fleurentin J.,
Lanhers M. C.,
Misslin R.,
Mortier F.
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.884
Subject(s) - flumazenil , anxiolytic , pharmacology , sedative , analgesic , benzodiazepine , pentylenetetrazol , muscle relaxant , convulsant , chemistry , medicine , receptor , anticonvulsant , epilepsy , biochemistry , psychiatry
Abstract An aqueous alcohol extract of Eschscholzia californica (Ec) has been evaluated for benzodiazepine, neuroleptic, antidepressant, antihistaminic and analgesic properties, in order to complete the study of the sedative and anxiolytic effects previously demonstrated. The plant extract did not protect mice against the convulsant effects of pentylenetetrazol, and did not cause muscle relaxant effects but appeared to possess an affinity for the benzodiazepine receptor: thus, flumazenil, an antagonist of these receptors, suppressed the sedative and anxiolytic effects of the extract. The Ec extract induced peripheral analgesic effects in mice but did not possess antidepressant, neuroleptic or antihistaminic effects.