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Effects of Melilotus officinalis on acute inflammation
Author(s) -
PleşcaManea Luminiţa,
Pârvu Alina Elena,
Pârvu M.,
Taaˇmaş M.,
Buia R.,
Puia M.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.875
Subject(s) - inflammation , coumarin , pharmacology , chemistry , hydrocortisone , melilotus , sodium , medicine , biochemistry , immunology , biology , botany , organic chemistry
Our study investigated the effects of Melilotus officinalis L. extract, containing 0.25% coumarin, on acute inflammation induced with oil of turpentine in male rabbits. The results were compared with those from a group treated with hydrocortisone sodium hemisuccinate and one injected with coumarin before inflammation was induced. The effects were evaluated by measuring serum citrulline, a test of in vitro phagocytosis, total leukocyte count and differential leukocyte count expressed as a percentage. M. officinalis had antiinflammatory effects because it reduced the activation of circulating phagocytes and lowered citrulline production. These properties were similar to those of hydrocortisone sodium hemisuccinate and coumarin. In the bone marrow acute phase response, M. officinalis had an inhibitory action that was lower than that of hydrocortisone sodium hemisuccinate and similar to coumarin. Copyright © 2002 John Wiley & Sons, Ltd.