Inhibitory effects of echinoisoflavanone and sophoraisoflavanone D in  Sophora chrysophylla  SEEM on copper ion‐induced protein oxidative modification of mouse brain homogenate  in vitro | Zendy

Toda Shizuo | Zendy; Shirataki Yoshiaki | Zendy

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Inhibitory effects of echinoisoflavanone and sophoraisoflavanone D in Sophora chrysophylla SEEM on copper ion‐induced protein oxidative modification of mouse brain homogenate in vitro

Author(s) -

Toda Shizuo,

Shirataki Yoshiaki

Publication year - 2002

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.869

Subject(s) - in vitro , oxidative stress , mannitol , edaravone , oxidative phosphorylation , free radical scavenger , chemistry , sophora , biochemistry , copper , hydroxyl radical , inhibitory postsynaptic potential , scavenger , pharmacology , biology , antioxidant , medicine , organic chemistry , endocrinology , alternative medicine , traditional chinese medicine , pathology

We present the results of an in vitro investigation of the inhibitory effects of echinoisoflavanone and sophoraisoflavanone D isolated from Sophora chrysophylla SEEM on copper‐induced protein oxidative modification of mouse brain homogenate in vitro . They inhibited copper‐induced protein oxidative modification. The order of inhibitory effects of these isoflavanones and mannitol as a hydroxyl radical scavenger was sophoraisoflavanone D > mannitol > echinoisoflavanone. The results suggest that these natural products may be of use in cases where oxidative stress is present. Copyright © 2002 John Wiley & Sons, Ltd.

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