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Inhibitory effects of echinoisoflavanone and sophoraisoflavanone D in Sophora chrysophylla SEEM on copper ion‐induced protein oxidative modification of mouse brain homogenate in vitro
Author(s) -
Toda Shizuo,
Shirataki Yoshiaki
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.869
Subject(s) - in vitro , oxidative stress , mannitol , edaravone , oxidative phosphorylation , free radical scavenger , chemistry , sophora , biochemistry , copper , hydroxyl radical , inhibitory postsynaptic potential , scavenger , pharmacology , biology , antioxidant , medicine , organic chemistry , endocrinology , alternative medicine , traditional chinese medicine , pathology
We present the results of an in vitro investigation of the inhibitory effects of echinoisoflavanone and sophoraisoflavanone D isolated from Sophora chrysophylla SEEM on copper‐induced protein oxidative modification of mouse brain homogenate in vitro . They inhibited copper‐induced protein oxidative modification. The order of inhibitory effects of these isoflavanones and mannitol as a hydroxyl radical scavenger was sophoraisoflavanone D > mannitol > echinoisoflavanone. The results suggest that these natural products may be of use in cases where oxidative stress is present. Copyright © 2002 John Wiley & Sons, Ltd.