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Synthesis of plumbagin derivatives and their inhibitory activities against Ehrlich ascites carcinoma in vivo and Leishmania donovani Promastigotes in vitro
Author(s) -
Hazra Banasri,
Sarkar Rajes,
Bhattacharyya Saswati,
Ghosh Prabir K.,
Chel Gautam,
Dinda Biswanath
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.867
Subject(s) - plumbagin , in vitro , in vivo , leishmania donovani , naphthoquinone , ehrlich ascites carcinoma , pharmacology , biology , derivative (finance) , leishmania , chemistry , biochemistry , leishmaniasis , immunology , botany , visceral leishmaniasis , microbiology and biotechnology , economics , financial economics , parasite hosting , world wide web , computer science
Plumbagin, a plant‐derived bioactive naphthoquinonoid compound, was converted to a hydroquinonoid derivative, which was studied for its tumour‐inhibitory and antileishmanial activities for the first time. A similar chemical transformation was undertaken on an analogous dimeric compound, diospyrin, and its bioassay results were compared with those of the plumbagin derivative. Synthesis of the derivative of plumbagin did not result in a marked enhancement of the tumour‐inhibitory activity, whereas the improvement was obvious in the case of diospyrin vis à vis its hydroquinonoid analogue. The conversion of diospyrin to the hydroquinonoid compound also led to a substantial increase in the antileishmanial activity, while a similar conversion of plumbagin failed to do so. Copyright © 2002 John Wiley & Sons, Ltd.