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Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana
Author(s) -
Du XiaoMing,
Sun NingYi,
Takizawa Nanako,
Guo YongTian,
Shoyama Yukihiro
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.862
Subject(s) - anticonvulsant , picrotoxin , sedative , glycoside , pentobarbital , pharmacology , anticonvulsant drugs , chemistry , pharmacognosy , biological activity , medicine , traditional medicine , epilepsy , stereochemistry , biochemistry , gabaa receptor , in vitro , receptor , psychiatry
Goodyerin is a flavonol glycoside isolated from the whole plants of Goodyera schlechtendaliana which has been used as a substitute for the crude drug, Anoectochilus formosanus . The pharmacological properties of goodyerin were assayed for effects on spontaneous locomotor activity, on pentobarbital‐induced hypnosis, and on anticonvulsant activity against picrotoxin‐induced seizures in rodents. Goodyerin exhibited a significant and dose‐dependent sedative and anticonvulsant effect. Copyright © 2002 John Wiley & Sons, Ltd.