Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from  Goodyera schlechtendaliana | Zendy

Du XiaoMing | Zendy; Sun NingYi | Zendy; Takizawa Nanako | Zendy; Guo YongTian | Zendy; Shoyama Yukihiro | Zendy

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Sedative and anticonvulsant activities of goodyerin, a flavonol glycoside from Goodyera schlechtendaliana

Author(s) -

Du XiaoMing,

Sun NingYi,

Takizawa Nanako,

Guo YongTian,

Shoyama Yukihiro

Publication year - 2002

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.862

Subject(s) - anticonvulsant , picrotoxin , sedative , glycoside , pentobarbital , pharmacology , anticonvulsant drugs , chemistry , pharmacognosy , biological activity , medicine , traditional medicine , epilepsy , stereochemistry , biochemistry , gabaa receptor , in vitro , receptor , psychiatry

Goodyerin is a flavonol glycoside isolated from the whole plants of Goodyera schlechtendaliana which has been used as a substitute for the crude drug, Anoectochilus formosanus . The pharmacological properties of goodyerin were assayed for effects on spontaneous locomotor activity, on pentobarbital‐induced hypnosis, and on anticonvulsant activity against picrotoxin‐induced seizures in rodents. Goodyerin exhibited a significant and dose‐dependent sedative and anticonvulsant effect. Copyright © 2002 John Wiley & Sons, Ltd.

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