Inhibition of intestinal motility by methanol extracts of  Hibiscus sabdariffa  L. (Malvaceae) in rats | Zendy

Salah A. M. | Zendy; Gathumbi J. | Zendy; Vierling W. | Zendy

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Inhibition of intestinal motility by methanol extracts of Hibiscus sabdariffa L. (Malvaceae) in rats

Author(s) -

Salah A. M.,

Gathumbi J.,

Vierling W.

Publication year - 2002

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.846

Subject(s) - hibiscus sabdariffa , malvaceae , pharmacology , papaverine , traditional medicine , chemistry , ic50 , quercetin , pharmacognosy , hibiscus , motility , biological activity , biology , medicine , biochemistry , botany , in vitro , endocrinology , antioxidant , genetics

The methanol extracts of Hibiscus sabdariffa ( p < 0.01) showed a significant dose dependent relaxant effect (IC 50 = 350 μ M ) on rat ileal strip comparable to the effect shown by nifedipin and papaverine as reference compounds. Similarly, the extract when administered intraperitoneally significantly ( p < 0.05–0.01) reduced the intestinal transit (13%–35%) in rats (IC 50 = 250 μ M ). The extracts (40% ± 04%) and nifedipin (51% ± 05%) also potentiated the diarrhoea inducing effect of castor oil (IC 50 = 350 μ M ). It is postulated that these effects are possibly generated by constituents such as quercetin and eugenol via a Ca 2+ channel modulated mode of action. Copyright © 2002 John Wiley & Sons, Ltd.

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