Premium
Inhibition of intestinal motility by methanol extracts of Hibiscus sabdariffa L. (Malvaceae) in rats
Author(s) -
Salah A. M.,
Gathumbi J.,
Vierling W.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.846
Subject(s) - hibiscus sabdariffa , malvaceae , pharmacology , papaverine , traditional medicine , chemistry , ic50 , quercetin , pharmacognosy , hibiscus , motility , biological activity , biology , medicine , biochemistry , botany , in vitro , endocrinology , antioxidant , genetics
Abstract The methanol extracts of Hibiscus sabdariffa ( p < 0.01) showed a significant dose dependent relaxant effect (IC 50 = 350 μ M ) on rat ileal strip comparable to the effect shown by nifedipin and papaverine as reference compounds. Similarly, the extract when administered intraperitoneally significantly ( p < 0.05–0.01) reduced the intestinal transit (13%–35%) in rats (IC 50 = 250 μ M ). The extracts (40% ± 04%) and nifedipin (51% ± 05%) also potentiated the diarrhoea inducing effect of castor oil (IC 50 = 350 μ M ). It is postulated that these effects are possibly generated by constituents such as quercetin and eugenol via a Ca 2+ channel modulated mode of action. Copyright © 2002 John Wiley & Sons, Ltd.