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Influence of Terminalia chebula on dermal wound healing in rats
Author(s) -
Suguna Lonchin,
Singh Surjeet,
Sivakumar Pitchumani,
Sampath Padmavathi,
Chandrakasan Gowri
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.827
Subject(s) - terminalia chebula , traditional medicine , antioxidant , medicine , wound healing , staphylococcus aureus , antimicrobial , peroxide , antibacterial activity , lipid peroxide , granulation tissue , pharmacology , surgery , biochemistry , chemistry , lipid peroxidation , microbiology and biotechnology , biology , bacteria , organic chemistry , genetics
Abstract The effects of topical administration of an alcohol extract of the leaves of an evergreen plant, Terminalia chebula , on the healing of rat dermal wounds, in vivo , was assessed. T. chebula treated wounds healed much faster as indicated by improved rates of contraction and a decreased period of epithelialization. Biochemical studies revealed a significant increase in total protein, DNA and collagen contents in the granulation tissues of treated wounds. The levels of hexosamine and uronic acid in these tissues, also increased up to day 8 post‐wounding. Reduced lipid peroxide levels in treated wounds, as well as ESR measurement of antioxidant activity by DPPH radical quenching, suggested that T. chebula possessed antioxidant activities. The tensile strength of tissues from extract‐treated incision wounds increased by about 40%. In addition, T. chebula possessed antimicrobial activity and was active largely against Staphylococcus aureus and Klebsiella . These results strongly document the beneficial effects of T. chebula in the acceleration of the healing process. Copyright © 2002 John Wiley & Sons, Ltd.