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Antiinflammatory activity of rotenoids from Clitoria fairchildiana
Author(s) -
Pereira da Silva Bernadete,
Paz Parente José
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.807
Subject(s) - vascular permeability , traditional medicine , chemistry , peritoneal cavity , pharmacology , biology , medicine , anatomy , endocrinology
Five structurally related rotenoids were isolated from the roots of Clitoria fairchildiana . The antiinflammatory activity was investigated using a capillary permeability assay. The protective effect was measured as the inhibition in vascular permeability produced by acetic acid in the peritoneal cavity. The results suggest that for maximum activity the maintenance of the B/C ring junction integrity is important. These findings support the traditional use of Clitoria species extracts in the treatment of inflammatory conditions. Copyright © 2002 John Wiley & Sons, Ltd.