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Cytotoxic activity of amooranin and its derivatives
Author(s) -
Rabi T,
Karunagaran D,
Krishnan Nair M,
Bhattathiri V. N
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.803
Subject(s) - hela , cytotoxic t cell , cytotoxicity , ic50 , in vivo , triterpene , chemistry , stereochemistry , in vitro , derivative (finance) , biochemistry , pharmacology , biology , medicine , pathology , alternative medicine , microbiology and biotechnology , economics , financial economics
Amooranin, 25‐hydroxy‐3‐oxoolean‐12‐en‐28‐oic acid, is a triterpene acid isolated from Amoora rohituka stem bark. The cytotoxic effects of amooranin and its derivatives were studied. Amooranin and its methyl ester showed greater cytotoxicity against MCF‐7 and HeLa cells derived from tumour tissues with a 50% inhibitory concentration (IC 50 ) of 1.8–3.4 μg/mL, compared with Chang liver cells from normal tissue with an IC 50 of 6.2–6.4 μg/mL, but amooranin exhibited no activity on HEp‐2 and L‐929 cells. However, its monoacetate derivative showed no inhibitory activity at 1–10 μg/mL dose levels. Of the cytotoxic isolates, the methyl ester derivative was inactive in in vivo evaluations in the Ehrlich ascites tumour cells at 50 and 100 mg/kg/day, demonstrating T/C values of 106% and 114%, respectively. Copyright © 2002 John Wiley & Sons, Ltd.