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The first clinical trial of topical application of procyanidin B‐2 to investigate its potential as a hair growing agent
Author(s) -
Takahashi Tomoya,
Kamimura Ayako,
Yokoo Yoshiharu,
Honda Shinkichi,
Watanabe Yasushi
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.800
Subject(s) - proanthocyanidin , placebo , medicine , placebo group , scalp , gastroenterology , chemistry , dermatology , biochemistry , pathology , antioxidant , polyphenol , alternative medicine
Procyanidin B‐2 is a compound we have identified in apple which acts as a growth‐promoting factor on murine hair epithelial cells. This report describes our investigation of the hair‐growing effects of 1% procyanidin B‐2 tonic after sequential use for 4 months. A double‐blind clinical trial was performed, involving a total of 29 subjects (procyanidin B‐2, 19 men; placebo, 10 men). No adverse side effects were observed in either group. In the procyanidin B‐2 group, 78.9% showed an increased mean value of hair diameter, whereas only 30.0% in the placebo group showed any increase ( p < 0.02, Fisher's exact probability test). The increased ratio of hairs measuring more than 40 μm in diameter after 4 months of procyanidin B‐2 treatment was significantly higher than that of the placebo controls ( p < 0.05, two‐sample t ‐test). The increase in number of total hairs in the designated scalp area (0.25 cm 2 ) of procyanidin B‐2 subjects after a 4 month trial was significantly greater than that of the placebo controls (procyanidinB‐2, 3.67 ± 4.09 (mean ± SD)/0.25 cm 2 ; placebo, −2.54 ± 4.00/0.25 cm 2 ; p < 0.001, two‐sample t ‐test). Procyanidin B‐2 therapy shows potential as a promising cure for male pattern baldness. Copyright © 2001 John Wiley & Sons, Ltd.