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Potential immunosuppressive and antiinflammatory activities of Malaysian medicinal plants characterized by reduced cell surface expression of cell adhesion molecules
Author(s) -
Tanaka Shigeo,
Yoichi Sakata,
Ao Lixi,
Matumoto Mariko,
Morimoto Katsushi,
Akimoto Naoshige,
Honda Gisho,
Tabata Mamoru,
Oshima Tikashi,
Masuda Toru,
Zaini bin Asmawi Mohd,
Ismail Zhari,
Yusof Sharom Mohd,
Din Laily B.,
Said Ikram M.
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.778
Subject(s) - cell adhesion molecule , cell adhesion , vcam 1 , biology , icam 1 , adhesion , traditional medicine , intercellular adhesion molecule 1 , medicinal plants , intercellular adhesion molecule , immune system , cell , chemistry , botany , biochemistry , immunology , medicine , organic chemistry
Abstract In the search for agents effective against immune‐mediated disorders and inflammation, we have screened Malaysian medicinal plants for the ability to inhibit the expression of intercellular adhesion molecule‐1 (ICAM‐1) and vascular cell adhesion molecule‐1 (VCAM‐1) on the surface of murine endothelial cells (F‐2), and mouse myeloid leukaemia cells (M1), respectively. Of 41 kinds (29 species, 24 genera, 16 families) of Malaysian plants tested, 10 and 19 plant samples significantly downregulated the expression of ICAM‐1 and VCAM‐1, respectively. Bioassay‐directed fractionation of an extract prepared from the bark of Goniothalamus andersonii showed that its ingredients, goniothalamin (1) and goniodiol (2) inhibited the cell surface expression of both ICAM‐1 and VCAM‐1 . The present results suggest that Malaysian medicinal plants may be abundant natural resources for immunosuppressive and antiinflammatory substances. Copyright © 2001 John Wiley & Sons, Ltd.