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Estimation of triterpenoids from Heliotropium marifolium Koen. ex Retz. in vivo and in vitro . I. Antimicrobial screening
Author(s) -
Singh B.,
Dubey M. M.
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.759
Subject(s) - friedelin , antimicrobial , penicillium chrysogenum , aspergillus niger , minimum inhibitory concentration , traditional medicine , microbiology and biotechnology , terpenoid , ex vivo , biology , triterpene , potency , minimum bactericidal concentration , triterpenoid , chemistry , in vitro , biochemistry , medicine , alternative medicine , pathology
The hexane extract of Heliotropium marifolium yielded a mixture of triterpenoids: β‐sitosterol, stigmasterol, β‐amyrin, friedelan‐3β‐ol (epifriedelenol), cycloartenone, β‐amyrin acetate, friedelin and epifriedenyl acetate. Isolated triterpenoid and reference antibiotics (gentamycin/mycostatin) were tested against selected pathogenic bacteria and fungi, e.g. Escherichia coli, Staphylococcus aureus, Aspergillus niger and Penicillium chrysogenum . The inhibition zone (IZ) and the activity index (AI) of isolated compounds were recorded and it was found that epifriedenyl acetate (IZ = 17; AI = 1.06) was the most active. The present study deals with the quantification and assessment of their growth inhibitory potency. It has been reported that cycloartenone was the major triterpenoid in both in vivo (0.54%) and in vitro (0.11%) cell cultures. Copyright © 2001 John Wiley & Sons, Ltd.