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Investigation of the larvicidal activity of Pothomorphe peltata and isolation of the active constituent
Author(s) -
Mongelli E.,
Coussio J.,
Ciccia G.
Publication year - 2002
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.753
Subject(s) - aedes aegypti , piperaceae , traditional medicine , biological activity , pharmacognosy , biology , larvicide , fractionation , larva , piper , botany , chemistry , chromatography , biochemistry , in vitro , medicine
The insecticidal activity of the leaves of Pothomorphe peltata (Piperaceae) was evaluated on Aedes aegypti larvae. The active methanol extract was subjected to a bioactivity‐directed fractionation, monitored by the larvicidal assay, and led to the isolation of a catechol derivative, 4‐nerolidylcatechol. This compound was quite potent against Aedes aegypti larvae (LC 50 = 9.1 µg/mL). Copyright © 2002 John Wiley & Sons, Ltd.