Inhibitory effect on immunoglobulin E production  in vivo  and  in vitro  by  Siegesbeckia glabrescens | Zendy

Kim HyungMin | Zendy; Lee JoonHo | Zendy; Won JinHee | Zendy; Park EunJeung | Zendy; Chae HanJung | Zendy; Kim HyungRyong | Zendy; Kim CheorlHo | Zendy; Baek SeungHwa | Zendy

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Inhibitory effect on immunoglobulin E production in vivo and in vitro by Siegesbeckia glabrescens

Author(s) -

Kim HyungMin,

Lee JoonHo,

Won JinHee,

Park EunJeung,

Chae HanJung,

Kim HyungRyong,

Kim CheorlHo,

Baek SeungHwa

Publication year - 2001

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.749

Subject(s) - immunoglobulin e , in vivo , lipopolysaccharide , in vitro , bordetella pertussis , ovalbumin , spleen , antibody , chemistry , immunology , biology , immune system , biochemistry , genetics , microbiology and biotechnology , bacteria

Elevated levels of immunoglobulin (Ig)E are associated with immediate‐type allergic reactions. The effect of an aqueous extract of Siegesbeckia glabrescens (Compositae) whole plants (SGWP) on in vivo and in vitro IgE production was studied in mice. SGWP dose‐dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and Bordetella pertussis toxin absorbed to aluminium hydroxide gel. SGWP dose‐dependently inhibited IL‐4‐dependent IgE production by lipopolysaccharide‐stimulated murine whole spleen cells. In the case of U266 human IgE‐bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti‐allergic activity by inhibiting IgE production from B cells. Copyright © 2001 John Wiley & Sons, Ltd.

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