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The synthesis of Rantes, G‐CSF, IL‐4, IL‐5, IL‐6, IL‐12 and IL‐13 in human whole‐blood cultures is modulated by an extract from Eleutherococcus senticosus L. roots
Author(s) -
Schmolz M. W.,
Sacher F.,
Aicher B.
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.746
Subject(s) - potency , cytokine , pharmacology , stimulation , ethanol , whole blood , pharmacognosy , traditional medicine , medicine , in vitro , chemistry , biological activity , immunology , biochemistry , endocrinology
An ethanol extract derived from the roots of Eleutherococcus senticosus was found to influence markedly the cytokine synthesis of activated whole blood cultures of ten healthy volunteers. Whereas the synthesis of Rantes was increased over a wide range of concentrations, the release of IL‐4, IL‐5 and IL‐12 was significantly inhibited. An inhibition at higher concentrations, switching to a stimulation at lower doses of the extract was seen with G‐CSF, IL‐6 and IL‐13. From these particular immuno‐pharmacological effects of Eleutherococcus senticosus we suggest this herbal preparation possesses immuno‐modulatory potency, rather than just being immuno‐suppressive or ‐stimulating. Copyright © 2001 John Wiley & Sons, Ltd.