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Chemoprotective effect of Ixora coccinea L. flowers on cisplatin induced toxicity in mice
Author(s) -
Latha P. G.,
Panikkar K. R.
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.727
Subject(s) - chemoprotective , cisplatin , pharmacology , toxicity , antioxidant , chemistry , pharmacognosy , toxicology , traditional medicine , medicine , biochemistry , biology , biological activity , chemotherapy , in vitro , organic chemistry
The active fraction from Ixora coccinea flowers prevented a decrease in body weight, haemoglobin levels and leucocyte counts of mice treated with cisplatin. It also significantly prolonged the life span of cisplatin treated mice and maintained their blood urea nitrogen levels in the near normal range, indicating its chemoprotective effects. Copyright © 2001 John Wiley & Sons, Ltd.