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Long term effect of aflatoxin B 1 on lipid peroxidation in rat liver and kidney: effect of picroliv and silymarin
Author(s) -
Rastogi Ravi,
Srivastava Arvind Kumar,
Rastogi Anil Kumar
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.722
Subject(s) - lipid peroxidation , aflatoxin , pharmacology , chemistry , carcinogen , antioxidant , toxicity , biochemistry , oxidative stress , lipid peroxide , biology , food science , organic chemistry
Aflatoxin B 1 (AFB 1 ) is a potent hepatotoxic and hepatocarcinogenic mycotoxin. The mechanism of cellular damage caused by AFB 1 has not been fully elucidated. Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenesis of many carcinogens. The present investigation aims at assessing the comparative antioxidant effet of picroliv, a standardized iridoid glycoside fraction of Picrorhiza kurroa and silymarin, a well known standard hepatoprotective, on aflatoxin B 1 induced lipid‐peroxidation in rat liver and kidney. Marked increases in lipid peroxide levels and a concomitant decrease in enzymic antioxidant levels were observed in aflatoxin B 1 (2 mg/kg, i.p) ‐toxicated rats, while drug (picroliv and silymarin both) treatment reversed the condition to near normal levels. The effects of picroliv and silymarin were comparable. Copyright © 2001 John Wiley & Sons, Ltd.