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Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials
Author(s) -
Marahatha Rishab,
Gyawali Kabita,
Sharma Kabita,
Gyawali Narayan,
Tandan Parbati,
Adhikari Ashma,
Timilsina Grishma,
Bhattarai Salyan,
Lamichhane Ganesh,
Acharya Ashis,
Pathak Ishwor,
Devkota Hari Prasad,
Parajuli Niranjan
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.7138
Subject(s) - medicine , withaferin a , rheumatoid arthritis , pharmacology , transrepression , mechanism (biology) , mechanism of action , bioinformatics , traditional medicine , immunology , withania somnifera , biology , biochemistry , philosophy , alternative medicine , epistemology , pathology , transactivation , transcription factor , in vitro , gene
Natural products and their derivatives are known to be useful for treating numerous diseases since ancient times. Because of their high therapeutic potentials, the use of different medicinal plants is possible to treat varied inflammation‐mediated chronic diseases. Among natural products, phytosteroids have emerged as promising compounds mostly because they have diverse pharmacological activities. Currently, available medications exert numerous systemic toxicities, including hypertension, immune suppression, osteoporosis, and metabolic abnormalities. Thus, further research on phytosteroids to subside these complications is of significant importance. In this study, the information on phytosteroids, their types, and actions against inflammation, and allergic complications was collected by a systematic survey of literature on several scientific search engines. The literature review suggested that phytosteroids exhibit antiinflammatory action via different modes through transrepression or selective COX‐2 enzymes. Also, in silico ADMET analysis was carried out on available phytosteroids to uncover their pharmacokinetic properties. Our analysis has shown that eight compounds: withaferin A, stigmasterol, β‐sitosterol, guggulsterone, diosgenin, sarsasapogenin, physalin A, and dioscin, −isolated from medicinal plants show similar pharmacokinetic properties as compared to dexamethasone, commercially available glucocorticoid. These phytosteroids could be useful for the treatment of inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, asthma, and cardiovascular diseases. Thus, systematic research is required to explore potent phytosteroids with lesser side effects, which might substitute the current medications.