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Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats
Author(s) -
Stanely Mainzen Prince P.,
Me Venugopal P.
Publication year - 2001
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.707
Subject(s) - tinospora cordifolia , alloxan , tbars , glibenclamide , antioxidant , thiobarbituric acid , traditional medicine , superoxide dismutase , diabetes mellitus , catalase , glutathione peroxidase , glutathione , pharmacology , medicine , phytotherapy , chemistry , endocrinology , lipid peroxidation , biochemistry , enzyme , alternative medicine , pathology
Tinospora cordifolia is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. Oral administration of 2.5 g and 5.0 g/kg body weight of the aqueous extract of the roots for 6 weeks resulted in a significant reduction in thiobarbituric acid reactive substances (TBARS) and an increase in reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in alloxan diabetic rats. The effect of Tinospora cordifolia root extract (TCREt) was most prominently seen in the case of rats given 5.0 g/kg body weight. The effect of TCREt was more effective than glibenclamide. Thus our study shows that TCREt exhibits antioxidant action in alloxan diabetes. Copyright © 2001 John Wiley & Sons, Ltd.