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Epigenetic targeting of cancer stem cells by polyphenols (cancer stem cells targeting)
Author(s) -
Ghasemi Sorayya,
Xu Suowen,
Nabavi Seyed Mohammad,
Amirkhani Mohammad Amir,
Sureda Antoni,
Tejada Silvia,
Lorigooini Zahra
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.7059
Subject(s) - epigenetics , cancer stem cell , cancer , dna methylation , biology , cancer research , stem cell , chromatin , cancer epigenetics , cancer cell , epigenetic therapy , bioinformatics , microbiology and biotechnology , genetics , gene expression , gene , histone methyltransferase
Epigenetic alterations are one of the main factors that disrupt the expression of genes and consequently, they have an important role in the carcinogenicity and the progression of different cancers. Cancer stem cells (CSCs) are accountable for the recurrence, metastasis, and therapeutic failure of cancer. The noticeable and specific pathways in CSCs can be organized by epigenetic mechanisms such as DNA methylation, chromatin remodeling, regulatory RNAs, among others. Since epigenetics modifications can be changed and reversed, it is a possible tool for cancer control and treatment. Epigenetic therapies against CSCs are emerging as a very new strategy with a good future expectation to treat cancer patients. Phenolic compounds are a vast group of substances with anticarcinogenic functions, antiinflammatory, and antioxidative activities. It seems these characteristics are related to neutralizing CSCs development, their microenvironment, and metabolism through epigenetic mechanisms. In the current work, the types of epigenetic changes known in these cells are introduced. In addition, some studies about the use of polyphenols acting through a variety of epigenetic mechanisms to counteract these cells will be reviewed. The reported results seem to indicate that the use of these phenolic compounds may be useful for CSCs defeat.