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Hesperidin‐rich ethanol extract from waste peels of Citrus limetta mitigates rheumatoid arthritis and related complications
Author(s) -
Babu Vineet,
Binwal Monika,
Kumari Renu,
Sen Sumati,
Kumar Akhilesh,
Mugale Madhav N.,
Shanker Karuna,
Kumar Narendra,
Bawankule Dnyaneshwar U.
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.7053
Subject(s) - hesperidin , medicine , rheumatoid arthritis , arthritis , pharmacology , analgesic , psoriatic arthritis , traditional medicine , immunology , pathology , alternative medicine
The aim of this study is to explore the possible pharmacological effects of fruit waste that may have a key role in converting the fruit waste into pharmaceutical agents. Citrus limetta (Rutaceae) is an important commercial citrus fruit crops used by juice processing industries. C . limetta peels are perishable waste material, which creates a big challenge in juice processing industries. Initial pharmaco‐chemical profile of peels' extracts revealed that the ethanol extract ( ClPs) has promising anti‐inflammatory activity and rich in hesperidin content. In vivo experimental pharmacology profile of ClPs against arthritis and related complications revealed that oral administration of ClPs significantly reduced the arthritis score and arthritis index in elbow and knee joints against collagen‐induced arthritis (CIA) in rats. Biochemical parameters include pro‐inflammatory cytokines (TNF‐α, IL‐6, and IL‐17A), and C‐RP level in blood serum of CIA rats further confirmed the anti‐arthritic profile of ClPs . Further individual experiments related to arthritis‐related complications in experimental animals demonstrated the analgesic, anti‐inflammatory, and antipyretic potential of ClPs in dose‐dependent manner. The result of this study suggests the suitability of ClPs as a drug‐like candidate for further investigation toward the management of arthritis and related complications.