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New insights into the role of the Nrf2 signaling pathway in green tea catechin applications
Author(s) -
Talebi Marjan,
Talebi Mohsen,
Farkhondeh Tahereh,
Mishra Gaurav,
İlgün Selen,
Samarghandian Saeed
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.7033
Subject(s) - gclm , autophagy , keap1 , oxidative stress , catechin , signal transduction , medicine , gclc , pharmacology , biology , bioinformatics , antioxidant , apoptosis , cancer research , microbiology and biotechnology , biochemistry , downregulation and upregulation , transcription factor , polyphenol , gene
Nuclear factor‐erythroid 2‐related factor 2 (Nrf2) is a transcriptional signaling pathway that plays a crucial role in numerous clinical complications. Pivotal roles of Nrf2 have been proved in cancer, autoimmune diseases, neurodegeneration, cardiovascular diseases, diabetes mellitus, renal injuries, respiratory conditions, gastrointestinal disturbances, and general disorders related to oxidative stress, inflammation, apoptosis, gelatinolysis, autophagy, and fibrogenesis processes. Green tea catechins as a rich source of phenolic compounds can deal with various clinical problems and manifestations. In this review, we attempted to focus on intervention between green tea catechins and Nrf2. Green tea catechins especially epigallocatechin gallate (EGCG) elucidated the protective role of Nrf2 and its downstream molecules in various disorders through Keap‐1, HO‐1, NQO‐1, GPx, GCLc, GCLm, NF‐kB cross‐link, kinases, and apoptotic proteins. Subsequently, we compiled an updated expansions of the Nrf2 role as a gate to manage and protect different disorders and feasible indications of green tea catechins through this signaling pathway. The present review highlighted recent evidence‐based data in silico, in vitro, and in vivo studies on an outline for future clinical trials.