Inhibitory effects of sanguinarine on monoamine oxidase activity in mouse brain | Zendy

Lee Sang Sun | Zendy; Kai Masaaki | Zendy; Lee Myung Koo | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Inhibitory effects of sanguinarine on monoamine oxidase activity in mouse brain

Author(s) -

Lee Sang Sun,

Kai Masaaki,

Lee Myung Koo

Publication year - 2001

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.703

Subject(s) - sanguinarine , monoamine oxidase , harmine , pharmacology , chemistry , alkaloid , biology , biochemistry , enzyme , stereochemistry

The effects of benzophenanthridine alkaloids, such as sanguinarine and chelidonine, on monoamine oxidase (MAO) activity in mouse brain were investigated. Sanguinarine showed an inhibitory effect on MAO activity in a concentration dependent manner (53.4% inhibition at 25 µ M ). However, chelidonine did not inhibit MAO activity. The IC 50 value of sanguinarine was 24.5 µ M . Sanguinarine inhibited non‐competitively MAO activity using kynuramine as a substrate. The K i value for sanguinarine was 22.1 µ M . These results suggest that sanguinarine partially contributes to the regulation of catecholamine content. Copyright © 2001 John Wiley & Sons, Ltd.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research