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Natural products: The role and mechanism in low‐density lipoprotein oxidation and atherosclerosis
Author(s) -
Zhang Shengyu,
Li Lingli,
chen Wenxu,
Xu Suowen,
Feng Xiaojun,
Zhang Lei
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.7002
Subject(s) - resveratrol , lipoprotein , medicine , arteriosclerosis , quercetin , mechanism (biology) , low density lipoprotein , population , pharmacology , antioxidant , chemistry , cholesterol , biochemistry , philosophy , epistemology , environmental health
Atherosclerosis is a chronic inflammatory, metabolic, and epigenetic disease, which leads to the life‐threatening coronary artery disease. Emerging studies from bench to bedside have demonstrated the pivotal role of low‐density lipoprotein (LDL) oxidation in the initiation and progression of atherosclerosis. This article hereby reviews oxidation mechanism of LDL, and the pro‐atherogenic and biomarker role of oxidized LDL in atherosclerosis. We also review the pharmacological effects of several representative natural products (vitamin E, resveratrol, quercetin, probucol, tanshinone IIA, epigallocatechin gallate, and Lycopene) in protecting against LDL oxidation and atherosclerosis. Clinical and basic research supports the beneficial effects of these natural products in inhibiting LDL oxidation and preventing atherosclerosis, but the data are still controversial. This may be related to factors such as the population and the dosage and time of taking natural products involved in different studies. Understanding the mechanism of LDL oxidation and effect of oxidized LDL help researchers to find novel therapies against atherosclerosis.