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Gentiopicroside prevents alcoholic liver damage by improving mitochondrial dysfunction in the rat model
Author(s) -
Zhang Yan,
Yang Xiaomei,
Wang Shuang,
Song Shuang,
Yang Xiudong
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6981
Subject(s) - pharmacology , antioxidant , radix (gastropod) , aspartate transaminase , traditional medicine , apoptosis , alanine transaminase , chemistry , phytotherapy , liver function , transaminase , biochemistry , mitochondrion , liver injury , medicine , biology , enzyme , botany , pathology , alkaline phosphatase , alternative medicine
Gentianae Radix et Rhizoma is a medical plant that is widely cultivated in China, North Korea, Japan, and Russia, and gentiopicroside is one of its major active compounds. In this study, the hepatoprotective activity of gentiopicroside on rats with alcoholic liver damage (ALD) was evaluated using the transaminase and blood lipid levels and antioxidant capacity. The potential mechanism of hepatoprotective effect of gentiopicroside was evaluated by mitochondrial function detection, gas chromatography–mass spectrometry (GC–MS) metabolomic analysis, and anti‐apoptosis analysis. Results showed that the gentiopicroside exhibited good hepatoprotective activity on rats with ALD by decreasing the transaminase levels, regulating the blood lipid levels, and increasing the antioxidant capacity. The potential mechanisms were related to regulating mitochondrial dysfunction by recovering mitochondrial membrane potential level, adenosine triphosphate concentration, activities of key enzymes in tricarboxylic acid cycle, and activities of complex I‐V, regulating micromolecular metabolism and anti‐apoptosis. These findings supported the further exploration of Gentianae Radix et Rhizoma as effective phytotherapy to prevent and treat ALD.