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Chlorogenic acid depresses cellular bioenergetics to suppress pancreatic carcinoma through modulating c‐Myc‐TFR1 axis
Author(s) -
Yang Hongbao,
Said Abdullahi Mohamed,
Huang Huimin,
Papa Akuetteh Percy David,
Jin Guihua,
Wu Shijia,
Ma Nengfang,
Lan Linhua,
Shangguan Fugen,
Zhang Qiyu
Publication year - 2021
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.6971
Subject(s) - bioenergetics , glycolysis , cell growth , in vivo , cell , cancer research , in vitro , biology , microbiology and biotechnology , chemistry , mitochondrion , biochemistry , metabolism
Pancreatic ductal adenocarcinoma (PDAC) is severe malignant tumor in human, the outcomes of PDAC is extremely poor. Here, we evaluated the potential anti‐tumor activity of chlorogenic Acid (CA) in PDAC. Here, we found CA was effective to suppress PDAC cell growth in vitro and in vivo. Importantly, we found overall oxygen consumption rate was significantly decreased in CA dose‐dependent manner. We also found glycolysis reverse was decreased in CA‐treated cells, while basal glycolysis and glycolytic capacity were not significantly changed. Mechanistically, we demonstrated TFR1 could be a novel downstream target of CA, which is essential for PDAC cell growth and cellular bioenergetics maintenance. Furthermore, we validated that CA‐reduced c‐Myc resulted to down‐regulation of TFR1, which contributes to mitochondrial respiration dysfunction and cell growth delay. Together, this study indicates that CA suppresses PDAC cell growth through targeting c‐Myc‐TFR1 axis and suggests CA could be considered as a promising compound for PDAC treatment.